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Carotene

Carotene: An Overview of Its History, Chemistry, Pharmacology, Positive and Negative Effects, Usage, Medicinal Usage, Combinations and Warnings

 

Carotene is a type of organic compound that is responsible for the yellow, orange, and red colors in many fruits and vegetables. It is a precursor of vitamin A and is essential for maintaining good vision, healthy skin, and a robust immune system. In this article, we will delve into the history, chemistry, pharmacology, positive and negative effects, usage, medicinal usage, combinations, warnings, and references of carotene.

 

History of Carotene

 

The discovery of carotene can be traced back to the early 19th century when researchers first identified it in carrots. The name "carotene" was derived from the Latin word "carota," which means carrot. In the 20th century, scientists discovered that carotene was not only present in carrots but also in other fruits and vegetables, such as sweet potatoes, pumpkins, and tomatoes. Today, carotene is known to be present in over 600 different types of plants.

 

Chemistry of Carotene

 

Carotene is a type of hydrocarbon that is composed of 40 carbon atoms and 56 hydrogen atoms. It is a tetraterpenoid and is classified as a carotenoid. Carotene is insoluble in water but soluble in fats and oils. The chemical formula of carotene is C40H56.

 

Pharmacology of Carotene

 

Carotene is a precursor of vitamin A, which means that it can be converted into vitamin A in the body. This conversion takes place in the liver and requires the presence of bile and pancreatic enzymes. Once converted into vitamin A, carotene plays a crucial role in maintaining good vision, healthy skin, and a robust immune system. Carotene is also a potent antioxidant and helps protect the body against oxidative stress.

 

Positive Effects of Carotene

 

Carotene has several positive effects on the body. It is essential for maintaining good vision, healthy skin, and a robust immune system. Carotene is also a potent antioxidant and helps protect the body against oxidative stress. Studies have shown that carotene may also have anti-cancer properties and may help reduce the risk of certain types of cancer.

 

Negative Effects of Carotene

 

Although carotene has several positive effects, excessive consumption of carotene-rich foods or supplements can lead to negative effects. One of the most common negative effects of carotene is the development of carotenemia, a condition in which the skin turns yellow-orange. Carotenemia is a benign condition and is not harmful, but it can be mistaken for jaundice. Excessive consumption of carotene supplements can also lead to vitamin A toxicity, which can cause nausea, vomiting, dizziness, and other symptoms.

 

Usage of Carotene

 

Carotene is found in many fruits and vegetables, such as carrots, sweet potatoes, pumpkins, and tomatoes. Consuming a diet rich in carotene can help maintain good vision, healthy skin, and a robust immune system. Carotene supplements are also available and can be used to help prevent or treat vitamin A deficiency.

 

Medicinal Usage of Carotene

 

Carotene has several medicinal uses. It is used to treat and prevent vitamin A deficiency, which can lead to night blindness, dry eyes, and other eye problems. Carotene is also used to treat and prevent certain types of cancer, such as lung cancer and prostate cancer. However, more research is needed to determine the exact role of carotene in cancer prevention and treatment.

 

Combinations with Carotene

 

Carotene is often combined with other nutrients, such as vitamin E and selenium, to enhance its antioxidant properties. These combinations may help protect the body against oxidative stress and reduce the risk of chronic diseases.

 

Warnings Regarding Carotene Consumption

 

Although carotene is generally safe, excessive consumption of carotene supplements can lead to vitamin A toxicity, which can cause nausea, vomiting, dizziness, and other symptoms. Pregnant women should also be cautious when consuming carotene supplements as excessive intake may lead to birth defects. People with certain medical conditions, such as liver disease and hypothyroidism, should also consult their healthcare provider before taking carotene supplements.

 

Conslusion

 

In conclusion, carotene is a vital nutrient that is essential for maintaining good vision, healthy skin, and a robust immune system. While carotene is generally safe, excessive consumption of carotene supplements can lead to vitamin A toxicity and other negative effects. It is always best to consume carotene-rich foods as part of a balanced diet, and if you are considering taking carotene supplements, you should consult your healthcare provider first.

 

References

 

1. Ribaya-Mercado JD, Blumberg JB. Lutein and zeaxanthin and their potential roles in disease prevention. J Am Coll Nutr. 2004;23(6 Suppl):567S-587S.

2. Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med. 2003;24(6):345-351.

3. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press; 2001.

4. Meyers KJ, Johnson EJ, Bernstein PS, et al. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am J Clin Nutr. 2003;78(3): 539-546.

5. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012;(3):CD007176.

 

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Updated on 30 Apr 2023