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Magnesium

Magnesium: A Comprehensive Guide to this Essential Mineral

Magnesium is an essential mineral that plays a vital role in many physiological processes in the human body. It is the fourth most abundant mineral in the body, with the majority of it being found in bones, teeth, and soft tissues. Magnesium is involved in over 300 enzymatic reactions and is essential for proper muscle and nerve function, maintaining a healthy immune system, and regulating blood pressure.

What is Magnesium?

Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a silvery-white metal that is highly reactive and is not found in its pure form in nature. Magnesium is typically found in minerals such as dolomite, magnesite, and carnallite. It was first discovered by Joseph Black in 1755.

History of Magnesium

Magnesium has been used for medicinal purposes for thousands of years. The ancient Egyptians used magnesium-containing minerals to treat a variety of ailments, including constipation and skin irritations. In the 19th century, magnesium was recognized as an essential mineral for the human body, and research on its role in physiology and medicine began.

Pharmacology of Magnesium

Magnesium plays a critical role in many physiological processes, including muscle and nerve function, blood pressure regulation, and protein synthesis. It is also essential for the formation of DNA and RNA, which are necessary for cell growth and division. Magnesium has been shown to have anti-inflammatory and antiplatelet effects, making it a potential therapeutic agent for a variety of conditions, including cardiovascular disease and diabetes.

Chemistry of Magnesium

Magnesium is a metal with a low density and a high melting point. It is highly reactive and readily forms compounds with other elements. Magnesium is essential for the proper function of many enzymes, and its role in ATP synthesis makes it essential for energy metabolism in cells. The most common form of magnesium found in supplements is magnesium oxide, which has a high bioavailability and is easily absorbed by the body.

Positive Effects of Magnesium

Magnesium has numerous positive effects on the human body. It is essential for proper muscle and nerve function, regulating blood pressure, and maintaining a healthy immune system. Magnesium has been shown to improve insulin sensitivity and may reduce the risk of type 2 diabetes. It is also beneficial for bone health, as it helps to regulate calcium metabolism and is involved in the formation of bone tissue.

Negative Effects of Magnesium

While magnesium is generally considered safe, taking high doses of magnesium supplements can lead to gastrointestinal symptoms such as diarrhea and abdominal cramping. In rare cases, excessive magnesium intake can lead to magnesium toxicity, which can cause nausea, vomiting, and cardiac arrest. Magnesium supplements can also interact with certain medications, such as antibiotics and diuretics.

Supplements to Boost Magnesium

There are several types of magnesium supplements available, including magnesium oxide, magnesium citrate, and magnesium glycinate. Magnesium oxide is the most commonly used form of magnesium supplement, but it can cause gastrointestinal symptoms in some people. Magnesium citrate is a highly bioavailable form of magnesium that is easily absorbed by the body. Magnesium glycinate is a chelated form of magnesium that is less likely to cause gastrointestinal symptoms than other forms of magnesium.

Warnings

It is important to talk to your healthcare provider before taking magnesium supplements, as they can interact with certain medications and may not be appropriate for people with certain medical conditions. High doses of magnesium supplements can cause gastrointestinal symptoms, and excessive intake can lead to magnesium toxicity.

Conclusion

Magnesium is an essential mineral that plays a critical role in many physiological processes in the human body. It is essential for proper muscle and nerve function, regulating blood pressure, and maintaining a healthy immune system. While magnesium supplements can be beneficial

in correcting magnesium deficiency, it is important to talk to your healthcare provider before taking them to ensure that they are safe and appropriate for your individual needs.

References

1. National Institutes of Health. Magnesium: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed April 22, 2023.

2. de Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in Man: Implications for Health and Disease. Physiol Rev. 2015;95(1):1-46.

3. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333.

4. Veronese N, Berton L, Carraro S, et al. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Clin Nutr. 2014;100(3):974-981.

5. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients. 2017;9(5):429.

6. Institute of Medicine (US) Committee on Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington (DC): National Academies Press (US); 1997. Available from: https://www.ncbi.nlm.nih.gov/books/NBK109820/

7. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev. 2012;70(3):153-164.

Updated on 22 Apr 2023