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Cysteine

What is Cysteine?

Cysteine is a non-essential amino acid that is found in many different types of proteins in the human body. It is one of the building blocks of the antioxidant glutathione, which is important for cellular health and detoxification. Cysteine is also a precursor to taurine, which is necessary for the proper functioning of the heart and brain.

History of Cysteine

Cysteine was first discovered in 1810 by the French chemist Louis-Nicolas Vauquelin. It was later isolated from human hair in 1899 by the German chemist Emil Fischer. In the early 20th century, cysteine was found to be an important component of many different types of proteins, including enzymes and antibodies.

Pharmacology of Cysteine

Cysteine is converted into cystine in the body, which is an important component of many different types of proteins. It is also a precursor to glutathione, which is a powerful antioxidant that helps to protect cells from damage caused by free radicals. Cysteine also plays a role in the detoxification of heavy metals and other harmful substances in the body.

Chemistry of Cysteine

Cysteine is a sulfur-containing amino acid with the chemical formula C3H7NO2S. It is one of the 22 amino acids that are used to build proteins in the human body. Cysteine contains a thiol group (-SH) that is highly reactive and can form disulfide bonds with other cysteine molecules.

Positive Effects of Cysteine

1. Antioxidant Properties: Cysteine is a precursor to glutathione, which is a powerful antioxidant that helps to protect cells from damage caused by free radicals.

2. Detoxification: Cysteine plays a role in the detoxification of heavy metals and other harmful substances in the body.

3. Immune Function: Cysteine is necessary for the production of antibodies, which are important for the immune system to function properly.

Negative Effects of Cysteine

1. Gastrointestinal Side Effects: High doses of cysteine supplements may cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea.

2. Interactions with Medications: Cysteine supplements may interact with certain medications, including nitroglycerin and chemotherapy drugs. Therefore, it is important to speak with a healthcare provider before supplementing with cysteine if you are taking any medications.

Supplements to Boost Cysteine

1. N-Acetyl Cysteine (NAC) Supplements: NAC is a form of cysteine that has been shown to have antioxidant and anti-inflammatory properties. It is also used to treat acetaminophen poisoning.

2. Whey Protein Supplements: Whey protein is a rich source of cysteine and other essential amino acids. It is commonly used as a dietary supplement to promote muscle growth and recovery.

Warnings about Cysteine

1. Allergies: Some people may be allergic to cysteine supplements, which can cause symptoms such as itching, hives, and difficulty breathing.

2. Interactions with Medications: Cysteine supplements may interact with certain medications, including nitroglycerin and chemotherapy drugs. Therefore, it is important to speak with a healthcare provider before supplementing with cysteine if you are taking any medications.

3. Dosage: The recommended dosage of cysteine supplements can vary depending on the individual and the reason for supplementation. It is important to follow the recommended dosage on the product label or speak with a healthcare provider to determine the appropriate dosage.

Conclusion

Cysteine is a non-essential amino acid that is important for many different functions in the human body. It is a precursor to glutathione, which is a powerful antioxidant that helps to protect cells from damage caused by free radicals. Cysteine also plays a role in the detoxification of heavy metals and other harmful substances in the body, as well as the production of antibodies for proper immune function.

While cysteine supplements can provide benefits for some individuals, it is important to exercise caution and speak with a healthcare provider before beginning supplementation. High doses of cysteine supplements may cause gastrointestinal side effects, and cysteine may interact with certain medications.

Sources of cysteine in the diet include foods such as poultry, eggs, dairy products, and legumes. Whey protein supplements are also a popular source of cysteine for those looking to boost their intake.

Overall, cysteine is an important amino acid with a variety of functions in the body. By understanding its benefits and potential risks, individuals can make informed decisions about whether or not to supplement with cysteine and how to incorporate it into a healthy diet.

References:

  1. Li, S., Tan, H. Y., Wang, N., & Feng, Y. (2018). Antioxidant properties of glutathione, cysteine, and N-acetyl-cysteine: a review of their past, present, and future roles in human health and disease. Oxidative medicine and cellular longevity, 2018.

  2. Pizzorno, J. (2014). Glutathione!. Integrative Medicine: A Clinician's Journal, 13(1), 8-12.

  3. Wu, G. (2009). Amino acids: metabolism, functions, and nutrition. Amino acids, 37(1), 1-17.

Updated on 22 Apr 2023