What is 1P-LSD?

1P-LSD is a psychedelic substance that has gained popularity in recent years. It is a derivative of LSD, which is one of the most well-known and widely used psychedelic drugs. This article will provide a comprehensive overview of 1P-LSD, including its history, chemistry, pharmacology, effects, usage, and warnings.

History of 1P-LSD

1P-LSD was first synthesized in the 1960s as a potential treatment for mental health conditions. However, it was never developed for this purpose and remained largely unknown until the early 2010s. It was first sold online as a legal alternative to LSD and quickly gained popularity among recreational drug users. Today, it is classified as a controlled substance in many countries, including the United States and the United Kingdom, as well as New Zealand where it is caught as a controlled substance analogue.

Chemistry of 1P-LSD

1P-LSD is a derivative of LSD, which is a lysergamide compound. It has a molecular formula of C23H29N3O2 and a molecular weight of 379.5 g/mol. Its chemical structure is similar to that of LSD, with a propionyl group added to the nitrogen atom of the indole ring.

Pharmacology of 1P-LSD

Like LSD, 1P-LSD acts as a serotonin receptor agonist, specifically binding to the 5-HT2A receptor. This leads to increased levels of serotonin in the brain, which can lead to altered perception, thought, and mood. The effects of 1P-LSD are similar to those of LSD, although they may be slightly less intense due to the presence of the propionyl group.

Effects of 1P-LSD

The effects of 1P-LSD are similar to those of LSD, although they may be slightly less intense due to the presence of the propionyl group. Users report altered perception, thought, and mood, as well as visual and auditory hallucinations. Physical effects can include increased heart rate and blood pressure, dilated pupils, and elevated body temperature. The duration of effects can vary from person to person, but typically last between 8-12 hours.

Usage of 1P-LSD

1P-LSD is typically consumed orally in the form of a blotter paper, which is placed on the tongue and allowed to dissolve. The dosage of 1P-LSD varies depending on the individual, but typical doses range from 50-150 micrograms. It is important to note that 1P-LSD is a highly potent drug and can have serious health consequences if misused.

Warnings about 1P-LSD

1P-LSD is a highly potent drug that can have serious health consequences if misused. Long-term use can lead to persistent changes in perception and mood, as well as psychological dependence. Overdose can also occur, which can lead to seizures, coma, and death. It is important to use 1P-LSD responsibly and under the supervision of a healthcare professional if possible.

Conclusion

In conclusion, 1P-LSD is a psychedelic substance that has gained popularity in recent years. It is a derivative of LSD and acts as a serotonin receptor agonist. The effects of 1P-LSD include altered perception, thought, and mood, as well as visual and auditory hallucinations. It is important to use 1P-LSD responsibly and under the supervision of a healthcare professional if possible.

References

1. Rickli, A., Luethi, D., Reinisch, J., Buchy, D., Hoener, M. C., Liechti, M. E. (2015). "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens." European Neuropsychopharmacology, 25(3), 365-376. doi: 10.1016/j.euroneuro.2014.12.006
2. Halberstadt, A. L., Geyer, M. A. (2018). "Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens." Neuropharmacology, 142, 68-74. doi: 10.1016/j.neuropharm.2018.08.027
3. Passie, T., Brandt, S. D. (2018). "Self-experiments with psychoactive substances: a historical perspective." Journal of Psychoactive Drugs, 50(4), 270-278. doi: 10.1080/02791072.2018.1474106
4. Nichols, D. E. (2016). "Psychedelics." Pharmacological Reviews, 68(2), 264-355. doi: 10.1124/pr.115.011478

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