What is Trans-nerolidol?

Trans-nerolidol is a terpene that is found in various plants, including cannabis. It is known for its woody and floral aroma and is often used in perfumes, soaps, and other beauty products. This terpene has been found to have a variety of potential medicinal properties, making it of interest to researchers.

History of Trans-nerolidol

Trans-nerolidol was first identified in the essential oil of neroli flowers in the 19th century. It is also found in other essential oils, such as jasmine and lemongrass oil. The terpene has been used in traditional medicine for centuries, particularly in Ayurvedic and Chinese medicine, for its sedative and anti-anxiety properties.

Chemistry of Trans-nerolidol

Trans-nerolidol has a chemical formula of C15H26O and a molecular weight of 222. It is a sesquiterpene alcohol that contains a double bond and an alcohol group. The terpene is soluble in organic solvents and has a boiling point of 256-257°C.

Pharmacology of Trans-nerolidol

Trans-nerolidol has been found to have a variety of potential medicinal properties. It has been shown to have sedative and anti-anxiety effects, making it a potential treatment for conditions such as anxiety and insomnia. Additionally, it has been found to have antioxidant and anti-inflammatory properties, making it useful in treating conditions such as arthritis and other inflammatory disorders.

Positive Effects of Trans-nerolidol

Some of the positive effects of Trans-nerolidol include:

• Sedative and anti-anxiety properties: Trans-nerolidol has been found to have a calming effect, making it useful for treating anxiety and insomnia.
• Antioxidant and anti-inflammatory properties: Trans-nerolidol has been found to have potential antioxidant and anti-inflammatory effects, making it useful in treating conditions such as arthritis and other inflammatory disorders.

Negative Effects of Trans-nerolidol

There are no known negative effects of Trans-nerolidol when used in moderation.

Combinations with Trans-nerolidol

Trans-nerolidol is often found in combination with other terpenes, such as myrcene and linalool. These terpenes may enhance the potential medicinal benefits of Trans-nerolidol.

Warnings

Trans-nerolidol is generally considered safe when used in moderation. However, it is important to note that high doses of this terpene may cause drowsiness and dizziness. It is important to use Trans-nerolidol in a well-ventilated area and to avoid excessive exposure.

Conclusion

Trans-nerolidol is a terpene that can be found in cannabis and other plants. It has a variety of potential medicinal properties, including sedative, anti-anxiety, antioxidant, and anti-inflammatory effects. While there are no known negative effects of this terpene, it is important to use it in moderation and to take precautions to avoid excessive exposure.

References

1. Ambrosio, S. R., de Oliveira, A. C., da Silva, L. R., Carvalho, C. P., & Maia, J. G. (2016). Trans-nerolidol, an effective component in reducing acute inflammatory response. Evidence-Based Complementary and Alternative Medicine, 2016.

2. de Sousa, D. P. (2011). Analgesic-like activity of essential oils constituents. Molecules, 16(3), 2233-2252.

3. Kim, S. H., Kim, H. S., Kim, Y. J., & Jeong, H. J. (2013). Inhibitory effect of trans-nerolidol on the LPS-induced inflammatory response in RAW264. 7 cells. Journal of Agricultural and Food Chemistry, 61(49), 11903-11909.

4. Martins, D. F., Emer, A. A., Batista, A. C., Rodrigues, M. F., & de Sousa, D. P. (2014). Anticonvulsant effect of nerolidol in mice: involvement of the GABAergic system. Zeitschrift für Naturforschung C, 69(7-8), 277-281.

5. Nogueira Neto, J. F., de Freitas, R. M., de Sousa, D. P., & de Aguiar, R. P. (2013). Antidepressant-like effects of trans-nerolidol in the forced swimming test and tail suspension test in mice. Pharmacology Biochemistry and Behavior, 111, 42-49.

6. Yang, Y. C., Lee, S. G., Lee, C. H., Clark, J. M., & Ahn, Y. J. (2006). Insecticidal activity of plant essential oils against Pediculus humanus capitis (Anoplura: Pediculidae). Journal of medical entomology, 43(4), 731-735.