Monoamine Oxidase Inhibitors (MAOIs)

What are Monoamine oxidase inhibitors (MAOIs)?

Monoamine oxidase inhibitors (MAOIs) are a class of compounds that inhibit naturally occurring enzymes in the human body. This inhibition leads to increased levels of chemicals such as the neurotransmitters serotonin and dopamine. By slowing their metabolism, MAOIs also allow certain chemicals to become active when taken orally, that would normally have no effects due to being metabolized too quickly. MAOIs have also been rumored to alter the effects of other substances including: Diviners Sage (Salvia divinorum).

Examples of  MAOIs

  • Ayahuasca vine (Banisteriopsis caapi)
  • Passion Flower (Passiflora incarnata) (mild)
  • Puncture-vine (Tribulus terrestris)
  • Some Anti depressant medications
  • Syrian Rue (Peganum harmala) seeds
  • Tobacco (mild)

The Danger of MAOIs

The danger of MAOIs is that they turn certain foods and medicines into poisons, which may cause a range of side effects including headaches, increased blood pressure, blurred vision and even death.

List of dangerous combination's

The following is a list of substances that should NOT be consumed 12 hours before to 12 hours after taking an MAO-inhibitor.

Very Dangerous

  • Alcohol
  • Amphetamines, (P, Meth, Speed, Ice, Uppers)
  • Anesthetics
  • Antidepressants
  • Bath Salts (Synthetic Legal Highs)
  • Cocaine
  • Cold and flu medication
  • Ephedrine
  • Hay-fever and allergy medication
  • Kanna (Sceletium tortuosum)
  • MDMA (XTC, Ecstasy)
  • Migraine medication
  • Phentermine
  • Pseudoephedrine
  • Sleeping pills (Downers, Benzos)
  • Synthetic Cannabinoids
  • Tramadol

Possibly Dangerous

  • Aged Cheese
  • Beans
  • Caffeine
  • Chocolate
  • Dairy products
  • Fruits
  • Ginseng
  • Meat, fish and eggs
  • Meat extracts
  • Mescaline Cacti (Peyote)
  • Morning glory or Hawaiian Baby Wood-rose seeds
  • Nasal sprays
  • Nutmeg
  • Nuts
  • Other MAO inhibitors
  • Pickled or salted fish
  • Sauerkraut
  • Sausage
  • Soy sauce
  • St Johns Wort
  • Sweet Flag (Acorus calamus)
  • Yeast

Further Information

Erowid MAO Inhibitors Vault

This article is provided for harm minimization purposes. You can read similar articles in our Knowledge Base.