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Monoamine oxidase inhibitors (MAOIs)

Updated on May 04, 2023

What are Monoamine oxidase inhibitors (MAOIs)

Monoamine oxidase inhibitors (MAOIs) are a class of compounds that inhibit naturally occurring enzymes in the human body. This inhibition leads to increased levels of chemicals such as the neurotransmitters serotonin and dopamine. By slowing their metabolism, MAOIs also allow certain chemicals to become active when taken orally, that would normally have no effects due to being metabolized too quickly. MAOIs have also been rumored to alter the effects of other substances including: Diviners Sage (Salvia divinorum).

 

Examples of  MAOIs

   

Ayahuasca vine (Banisteriopsis caapi)
Passion Flower (Passiflora incarnata) (mild)
Puncture-vine (Tribulus terrestris)
Some Anti depressant medications
Syrian Rue (Peganum harmala) seeds
Tobacco (mild)

 

The Danger of MAOIs

 

The danger of MAOIs is that they turn certain foods and medicines into poisons, which may cause a range of side effects including headaches, increased blood pressure, blurred vision and even death.

 

List of dangerous combination's

 

The following is a list of substances that should NOT be consumed 12 hours before to 12 hours after taking an MAO-inhibitor.

 

Very Dangerous

 

Alcohol
Amphetamines, (P, Meth, Speed, Ice, Uppers)
Anesthetics
Antidepressants
Bath Salts (Synthetic Legal Highs)
Cocaine
Cold and flu medication
Ephedrine
Hay-fever and allergy medication
Kanna (Sceletium tortuosum)
MDMA (XTC, Ecstasy)
Migraine medication
Phentermine
Pseudoephedrine
Sleeping pills (Downers, Benzos)
Synthetic Cannabinoids
Tramadol

 

Possibly Dangerous

   

Aged Cheese
Beans
Caffeine
Chocolate
Dairy products
Fruits
Ginseng
Meat, fish and eggs
Meat extracts
Mescaline Cacti (Peyote)
Morning glory or Hawaiian Baby Wood-rose seeds
Nasal sprays
Nutmeg
Nuts
Other MAO inhibitors
Pickled or salted fish
Sauerkraut
Sausage
Soy sauce
St Johns Wort
Sweet Flag (Acorus calamus)
Yeast

 

References

 

Erowid MAO Inhibitors Vault - https://erowid.org/chemicals/maois/

Erowid Ayahuasca Vault - https://erowid.org/chemicals/ayahuasca/ayahuasca.shtml

Erowid DMT Vault - https://erowid.org/chemicals/dmt/dmt.shtml

 

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