Here at MindFuel our focus is on experiencing and sharing the very best that mother-nature has to offer. Heavy duty synthetic chemicals are not really our thing. But while we do not encourage the use of synthetics, unless legally under medical supervision, we do understand there are many that will self-experiment regardless and who need accurate harm minimization information. Therefore we offer some unbiased facts regarding synthetic psychoactive substances for harm minimization purposes. If you choose to consume synthetic psychoactive substances we recommend you read our psychoactive substance harm minimization guide first. We also recommend you research your substance of choice via the links at the bottom of this page, paying particular attention to dosage, effects and contraindications. You can also use an EZ Test Kit to test that your choosen substance is actually what you think it is. No drug use is the safest option.



Claimed to be like a cross between MDMA and Mescaline. Potential in psychotherapy. It was available in the smartshops of Amsterdam in the late 90s, now days it is prohibited. Captured by New Zealand's controlled drug analogue laws and is therefore class C by default. If you do choose to use get an EZ Test Kit.

Amphetamines (P, Meth, Speed, Ice, Uppers)

Amphetamine and methamphetamine are pharmaceutical drugs used to treat a variety of conditions; when used recreationally, they are often referred to as speed or ice. They are highly addictive synthetic stimulants that promote energy, wakefulness, alertness and euphoria. They can be toxic to the heart (and lungs if smoked). Abuse or regular use can lead to amphetamine psychosis. We highly discourage amphetamine use unless under the advise of your medical professional. If you do choose to use, orally is the safest route of admin. Be sure to drink plenty of water to stay hydrated. avoid using more then once a month to help avoid addiction/dependence.

Alcohol (ethanol)

Alcohol is a legal high, a legally regulated psychoactive substance with CNS depressant effects that acts through the GABAₐ receptor. While legal and one of the most commonly used intoxicants in the world, Alcohol carries health risks, addiction potential and causes carnage to society in a level roughly similar to that of class a drugs. Long-term use can lead to dependence and/or addiction, in which case one must taper off slowly to avoid extremely unpleasant withdrawal effects which may include life-threatening seizures. If you choose to use alcohol do not mix with opiates or other downers. Try to leave at least 7 days between drinking binges to avoid addiction/dependence issues. You can reduce the harm by taking NAC with Vitamin C and Vitamin B6, 1 hour before drinking. Alternate each alcoholic drink with a drink of water. After drinking try taking B-Vitamins, Milk Thistle, Dandelion, Damiana, Fennel, Panax Ginseng and/or activated charcoal. to nurse a hangover try a tea with Meadow-sweet for head and stomach ache, Ginger and or Peppermint for nausea, Milk thistle, Dandelion to support liver, Damiana to support kidney's. Planning your meals around your drinking session can also help. Try a fatty meal for tea, with eggs on toast for breakfast. Essential oils may help. Peppermint for nausea. Lavender for shattered nerves. Orange for low mood. Rosemary for mental clarity. Lemon to detoxify and refresh.

Amyl Nitrate

Not psychoactive (as it only effects the body) but definitely synthetic. Poppers were hugely popular in the gay scene in the 1970's. They may make orgasm more intense and anal sex easier due to their muscle relaxing properties. Legal variants of the original brands such as Rush are still sold to this day in adult shops as leather cleaners or room deodorizers. One of the safest pharmaceuticals available when used correctly. If you decide to experiment with Popper's do not drink any or any get in your eyes or on your skin or lips. They are highly flammable so take care if smoking. Some users may experience a headache. Avoid Poppers if you have a heart, blood pressure or circulation issues. Amyl nitrate is also used by hunters as an antidote for cyanide poisoning.


Similar to Benzodiazepines. Popular in the 1970's, less common now days but still around. Prescribed for seizures. If you do choose to use follow the instructions on the pack or Google it. Do not mix with alcohol, opiates or other downers. Long-term use can lead to dependence and/or addiction, in which case one must taper off slowly to avoid extremely unpleasant withdrawal effects which may include life-threatening seizures.


Mothers little helpers. Valium is the most infamous benzo but there are many varieties, all with different strengths and duration of action. Benzodiazepines are prescribed to treat many conditions including severe anxiety and sleep problems. If you choose to use follow instructions on the pack or Google it. Do not mix with alcohol, opiates or other downers. Long-term use can lead to dependence and/or addiction, in which case one must taper off slowly to avoid extremely unpleasant withdrawal effects which may include life-threatening seizures.


Cocaine is a Class A controlled substance in New Zealand. Used by only a small minority in NZ until recently, it seems to be getting a little more popular here now days. Regular use often leads to addiction/dependence issues and is linked to nasal damage and heart attack. Expensive and usually cut with other substances such as caffeine, inositol or whatever is on hand. There is much suffering along the supply lines of Cocaine making it a Non-Fair-Trade drug. The coca shrub that Cocaine comes from is healthy, harmless and beneficial when used in its natural form as a tea or chewing quid. The problems start with extraction... Crack is Cocaine that has been cooked with baking soda to enable it to be smoked.  It is more addictive and has more side effects. If you do choose to use cocaine the safest route of admin is orally, followed by snorting. Get an EZ Test Cocaine Test kit to make sure you actually have Cocaine. The morning after cocaine use take our After C supplement before breakfast to minimize the depletion of neuro-transmitters. Aztec Fire may help restore nasal balance and harmony.


DMAA is stimulant that first showed up in the energy supplement AMP and later in NZ Party Pills. DMAA was claimed to be constituent of Geranium oil but was really a synthetic stimulant. Similar effect to ephedrine with similar side effects. Low dosage was the way to go with this one, large does or mixed with alcohol resulted in extreme nausea. Does not appear to have survived as an underground product since being prohibited but who knows whats in street pills these days. Still used in overseas bodybuilding energizers so be careful if importing supplements.


DXM is a dissociative and a cough suppressant. It was an ingredient in OTC cough formulas until recently, when it was scheduled as a pharmacy only medicine, making it harder for young people to obtain. If you do choose to use DXM, the main thing is to get the correct cough mixture, as the wrong kinds can contain ingredients that are toxic when a large dosage is taken. Do the research before you use, as there are some contraindications to consider. Avoid mixing with alcohol, opiates or downers. Long-term use may be habit-forming.

GHB, GBL 1,4-B (Fantasy, Liquid XTC, Rinse, Puritech CD Cleaner)

1,4-Butanediol is a clear inebriating liquid that is a pro-drug of GHB. It was available in NZ around 2000, sold as Puritech CD cleaner by Alphaware and as a dietary supplement by OuterSpace. They both got shut down and Alphaware were charged with preparing an unsafe food substance. 1,4-Butanediol and all related substances were scheduled as class b controlled drugs. They even prohibited the inactive GABA which does not cross the blood brain barrier. This makes a mockery of the MODA. If you choose to use do not mix with alcohol or other downers. Use a needless syringe to measure precise dosage, as overdose can kill. Try a small dosage first to test your reaction. Long-term use may be habit-forming.


Inhalants such as model airplane glue, butane and petrol are highly toxic to the brain other vital organs. Inhalants, especially glue-sniffing were very popular with street-kids in New Zealand during the 1980's. It was common to see a small group of youths passing around a plastic bag full of gunk and stumbling about in public places such as parks. While they were certainly best avoided, they were usually too inebriated to pose too much of a threat to the general public. Thankfully the fad seems to have faded away or at least been replaced by street grade synthetic cannabinoids. We strongly discourage anyone from even experimenting with inhalants. There are way better but far less toxic highs out there, just go an buy some weed or use poppers or NOS if you want to inhale something.


A dissociative anesthetic that was a prescription medicine but is now a controlled substance. Resent studies show it may be useful in fighting depression.


The choice of the 1960's counter-culture, LSD is a semi-synthetic psychedelic chemical discovered by chemist Albert Hoffman. Originally a tool for researchers and psychologists, it made its way our of the science lab and fueled the 60's counter-culture, changing music, film, art and the way people dressed, spoke and lived. Prohibited as Class A drug under MODA since the late 60's. Expected to eventually be rescheduled as prescription medicine or regulated psychoactive substance. Until then we can not recommend use. If you choose to use be aware of set and setting. LSD is best taken with a few close friends in a familiar environment. It is not a party drug. Get an EZ Test LSD Test Kit to make sure you actually have LSD. Other substances sold as blotter tabs such as N-Bomb are far more toxic than LSD which is non-toxic but can be overwhelming. When tripping always be sure to have some of our Trip Stopper supplement on hand just encase.


The love drug, MDMA (XTC, e, Molly, Eve, Disco Biscuits) appeared in the 1980's as a psychologists tool, especially for couples trying to sort out their differences. By the late 80's it had hit the emerging rave dance music scene and was prohibited by hippie hating authorities. Modern research shows multiple benefits in psychotherapy such as fighting depression and PTSD. If you do choose to use MDMA, get an EZ MDMA Test Kit to be sure you actually have MDMA. If your pill tests positive for PMA throw it away. The morning after taking MDMA, take our After E supplement before breakfast to minimize the depletion of your neuro-transmitters. If you use MDMA on a regular basis consider taking a 5-HTP supplement nightly for a cycle of up to 30 days. After 30 days have a break, otherwise your brain can get lazy and stop producing so much of its own serotonin.

Nitrous Oxide

Laughing Gas was sold in balloons from headshops and NOS bars in the early 2000's until Jim Anderton decided it was in fact a prescription medicine if sold for inhalation. You can still buy the Balloons and crackers in headshops, food and catering suppliers still sell the cream chargers. Cream chargers are also still available in sex shops for those with a cream fetish. Chronic use may result in B12 deficiency, therefore regular users would be wise to take a B Complex supplement.

Opioids - Synthetic

Highly addictive synthetic pain killers. Best saved for when you really need them for pain. If you do choose to use Opioids follow the instructions on the packet or Google it. The safest route of admin is orally. Do not mix with other downers or alcohol - these combinations can kill. Long-term use can lead to dependence and/or addiction, in which case one must taper off slowly to avoid extremely unpleasant withdrawal effects.


Angel dust. People used to lace joints with it in the 1980's, sending many unsuspecting users to the psych ward. Effects can be overwhelming. Most people prefer safer alternatives such as Ketamine, DXM or NOS.

Piperazines (BZP, TFMPP, Party Pills, Legal Highs)

The Piperazines appeared in so called herbal highs in the early 2000's. Originally made out to look like pepper and capsicum extracts, the substances turned out to be synthetic. BZP and related remained in legal Party Pills until they were banned in 2008. They are now class c, other than viagra (also a Piperazine) which was already scheduled as a prescription medicine.


Similar to Benzodiazepines. If you choose to use follow instructions on the product or google it. The safest route of admin is orally. Do not mix with alcohol or other downers. Long-term use can lead to dependence and/or addiction, in which case one must taper off slowly to avoid extremely unpleasant withdrawal effects which may include life-threatening seizures.

Research Chemicals

After the BZP bans the UK and various other countries replaced BZP with various other research chemicals. In New Zealand our strict analogue laws prevented this for the main part, although the odd supplier tried marketing various analogues. Some ended up with lengthy prison sentences.

Synthetic Cannabinoids, JWH-018, Spice, Sence

It was around 2005 that the first formulation of Spice appeared. It was $65 for a measly 400mg and marketed as a purely natural blend of exotic herbs. Because it was mild and expensive it did not get much attention for a year or two. Sence quickly followed and then many more brands came. What really saw a surge in popularity was the introduction of workplace drug testing. At the same time the cat was out the bag that the fake weed blends were not herbal at all but rather contained synthetic cannabinoids. The original chemical JWH-018 was smoother, milder, safer and more researched than  the blends that came next once the government started playing cat and mouse with the suppliers, creating a chaotic environment and the introduction of many barely researched compounds. The Key government banned the products all together in election year and things have gotten much worse since. We suggest anyone reading this to give these products a miss all-together, who knows what kinds of crap they are using now days. Things can only get worse until they legalize safe organic natural cannabis.


The Future is Unwritten

Aside from NOS or Poppers which are fairly harmless if used sensibly, we discourage the use of most of the above chemicals (the good ones are generally illegal resulting in poor quality controls in the manufacturing process, most of the others are just plain dirty substances to begin with). However that does not mean we are totally anti all chemicals. While we personally prefer natural substances, in theory in future we may be able to create new substances that provide many of the same benefits as the drugs above only without all the nasty side effects, addiction potential or legal and quality control risks. Take a molecule like alcohol - what if we could tweak it a little to result in a similar substance that can be drunk to get one pleasantly inebriated without the next-day hangover or other associated health-risks? That would be at least a positive improvement on the current situation. If nothing else the future will see the release of many interesting new compounds both medicinal and recreational. Perhaps we will see the development of new psychoactive substances that prove to be safe enough to be legalized and strictly regulated under the Psychoactive Substances Act 2016 (PSA). Or perhaps we will first see a lowering in schedule or legalizing and regulating under the PSA some of the safer of the currently prohibited chemicals such as MDMA and LSD.

Further Information

The Vaults of Erowid - Documenting the complex relationship between humans & psychoactives
Drugs-Forum - Addiction Help & Harm Reduction
MAPS - Multidisciplinary association for psychedelic studies


This article is a general guide intended for informational and/or harm minimization purposes only. Always do your own research and whenever in doubt ask your doctor. You can read similar articles in our Knowledge Base.