Monoamine Oxidase Inhibitors (MAOIs)

What are Monoamine oxidase inhibitors (MAOIs)?
Monoamine oxidase inhibitors (MAOIs) are a class of compounds that inhibit naturally occurring enzymes in the human body. This inhibition leads to increased levels of chemicals such as the neurotransmitters serotonin and dopamine. By slowing their metabolism, MAOIs also allow certain chemicals to become active when taken orally, that would normally have no effects due to being metabolized too quickly. MAOIs have also been rumored to alter the effects of other substances including: Diviners Sage (Salvia divinorum).

Examples of  MAOIs

  • Ayahuasca vine (Banisteriopsis caapi)
  • Syrian Rue (Peganum harmala) seeds.
  • Passion Flower (Passiflora incarnata) (mild).
  • Puncture-vine (Tribulus terrestris).
  • Some Anti depressant medications.
  • Tobacco (mild).
  • Possibly Cocoa (mild).

The Danger of MAOIs
The danger of MAOIs is that they turn certain foods and medicines into poisons, which may cause a range of side effects including headaches, increased blood pressure, blurred vision and even death.

List of dangerous combination's
The following is a list of substances that should NOT be consumed 12 hours before to 12 hours after taking an MAO-inhibitor.

Very Dangerous:
  • Antidepressants
  • Kanna (Sceletium tortuosum)
  • Tramadol
  • Cocaine.
  • Bath salts.
  • Amphetamines.
  • MDMA.
  • Mescaline cacti.
  • Migraine medication
  • Hay-fever and allergy medication
  • Cold and flu medication
  • Phentermine.
  • Ephedrine
  • Pseudoephedrine.
  • Sleeping pills
  • Anesthetics
  • Alcohol

Possibly Dangerous:

  • Chocolate.
  • Caffeine.
  • Ginseng.
  • Yeast.
  • Aged cheese.
  • Sausage.
  • Meat, fish and eggs.
  • Sauerkraut
  • Fruits.
  • Nuts.
  • Beans.
  • Soya sauce.
  • Morning glory or Hawaiian baby wood-rose seeds.
  • Nutmeg.
  • Acorus Calamus.
  • St Johns wort.
  • Nasal sprays.
  • Dairy products.
  • Pickled or salted fish.
  • Meat extracts.
  • Other MAO inhibitors.

Further Information:
Erowid MAOI vault.
Wiki MAOI page.


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